List of posters

Poster viewing I (Monday, 25 August)

Theme I – New Technologies
Theme II – Predictive Toxicology (sessions II-1 – II-10)

Poster viewing II (Tuesday, 26 August)

Theme II – Predictive Toxicology (sessions II-11 – II-17)
Theme III – 3Rs in Academia & Education
Theme IV – Communication, Dissemination and Data Sharing
Theme V – Efficacy and Safety Testing of Drugs and Biologicals

Poster viewing III (Wednesday, 27 August)

Theme VI – Human Relevance
Theme VII – Ethics
Theme VIII – Refinement and Welfare
Theme IX – Global Cooperation, Regulatory Acceptance and Standardization
Theme X – Additional sessions

 

Theme I – New Technologies

Session I-1: Virtual tissue models

I-1-416
Performance standards for human epidermis model Keraskin-VM for skin irritation alternatives
Y. Heo, K.-U. Yeo, W.-H. Jang, S.-S. An, K.-M. Lim, S.-H. Seok, J.-H. Che, Y.-S. Yun

I-1-657
Application of zebra fish and Neoderm®-ME, a new 3D pigmented skin model for the evaluation of anti-melanogenic effects of hexapeptoids; PAL-10 and PAL-12
M. Lee, K. E. Joo, K.-M. Lim

Session I-2: High throughput screening (HTS) models

I-2-227
A new approach to the automatic segmentation and evaluation of pigmentation lesion by using active contour model and speeded up robust features
M. Farshad, S. Mardani Samani, Z. Karimi, M. Yazdi

I-2-314
A novel in vitro model of spinal cord injury: validation and treatment strategies
S. D. Boomkamp, M. D. Houslay, S. C. Barnett

I-2-367
Physiological Oxygen Concentrations In A Sandwich Culture On Gas-Permeable Membranes Remarkably Enhance Rat Hepatocytes Functions And Genes Expression
W. Xiao, H. Matsui, M. Shinohara, K. Komori, T. Osada, Y. Sakai

I-2-371
A feasibility study into the biodistribution of test compounds in zebrafish embryos
J. McCormack, V. van der Weijden, T. Maarschalkerweerd, C. Snel, A. Menke, E. Hansen, F. Van Goethem, N. Mesens, A. Wolterbeek

I-2-477
Cellular Ellman's method adaptation using SH-SY5Y is a possibility for neurochemical multiparametric evaluation
R. Bachinski, L. Hummel, A. Linhares, A. Meyer, J. M. Granjeiro, G. G. Alves

I-2-491
A data analysis pipeline for Tox21 Phase II quantitative high throughput screening assays and its application to toxicity profiling of flame retardants
J.-H. Hsieh, A. Sedykh, M. Behl, R. Huang, M. Xia, R. Tice

I-2-582
Automation-compatible EST assay
S. Stroebel, D. Fluri, W. Moritz, J. M. Kelm

I-2-668
Evaluation Method in Bhas 42 Cell Transformation Assay Selecting Transformed Foci Using Hydrogen Peroxide, H2O2
K. Yamakage, D. Muramatsu, S. Arai, N. Endo, K. Sasaki

I-2-741
Using Skin-PAMPA for transdermal patch testing
B. Sinko, G. Vizseralek, K. Tsinman

Session I-3: Tissue on a chip / Human-on-a-chip

I-3-008
µ3DVasc: a novel microfluidic bioreactor setup for the reconstruction of vascularized 3D tissues in vitro
D. Ivannikov, I. Hebeiß, P. Nikolov, S. Giselbrecht, U. Schepers

I-3-037
Serial linkage of biochips toward an organ-on-chip approach
W. Wirths, J. Wiest, B. Wolf

I-3-101
Cell-based rapid and quantitative toxicity and efficacy monitoring in consecutive before and after the compound metabolism within liver for two ginger compounds at physiological concentration
T. Ona, J. Shibata

I-3-141
A multi-organ-chip co-culture of human liver equivalents and neurospheres for long-term substance testing
E.-M. Materne, A. Ramme, A. Lorenz, A. P. Terrasso, C. Brito, P. M. Alves, R. Lauster, U. Marx

I-3-152
Emulating the human vasculature in a multi-organ-chip platform
T. Hasenberg, E.-M. Materne, K. Schimek, S. Bauer, S. Brincker, A. Lorenz, R. Lauster, U. Marx

I-3-219
3D-printing: a new dimension for the 3R's
M van Zijverden, S Deleu

I-3-265
Long-term culture of dermal units in multi-organ-chips
K. Schimek, G. Lindner, B. Atac, A. Wanzek, D. Reissmann, I. Wagner, R. Lauster, U. Marx

I-3-301
Development of a 3-dimesional tissue with vascular networks in vitro
Y. Liu, S. Sakai, M. Taya

I-3-303
Synthesis and Characterization of Tunable Agarose-Gelatin Cryogel for Hepatotoxicity Evaluation
P. Balaji, S. Shanmugaapriya, M. A. Akbarsha

I-3-389
Neurotoxicity in vitro: assessment of the predictivity of neuronal networks coped to microelectrode arrays for identification of neurotoxicants
T. Ramirez, T. Weisschu, H. A. Huener, R. Landsiedel, B. van Ravenzwaay

I-3-590
Automated long-term operation of multi-organ-chips
L. Kloke, A. Jänicke, A. Ramme, F. Sonntag, C. Polk, F. Schmieder, M. Bürger, V. Artyushenko, U. Marx, R. Lauster

I-3-661
Substance exposure to skin and liver co-cultures in a Multi-Organ-Chip
I. Wagner, J. Hübner, T. Lade, R. Horland, A. Schepky, R. Lauster, J. Kuehnl, U. Marx

I-3-745
A new human liver 3D culture in microfluidic platform as a potential tool for toxicity studies
M. Jang, P. Neuzil, S.J. Trietsch, A. Manz

I-3-753
A Multi-Organ-Chip-based dynamic sensitization assay comprising human epidermis and primary dendritic cell co-culture
J. Hübner, I. Wagner, A. Lorenz, T. Lade, S. Gerlach, A. Schepky, J. Kühnl, R. Horland, R. Lauster, U. Marx

I-3-768
How new technologies are promising to fulfil the Reduction and Replacement 3Rs objectives
M. Lewis, J. M. Wilkinson, E. Kingsley

I-3-784
Kidney toxicity assessment and ADMET testing in a two-circuit microfluidic device
C. Drewell, A. Ramme, L. Aschauer, P. Jennings, F. Schmieder, F. Sonntag, R. Lauster, U. Marx

I-3-792
Microtissues meet microfluidic: A multi-parallel body on a chip concept
J.-Y. Kim, D. Fluri, J. G. Hengstler, R. Marchan, J. M. Kelm, A. Hierlemann, O. Frey

Session I-4: Novel 3D models

I-4-097
The Assessment of a Caco-2/CCD-18co Co-culture Model of the Small Intestine Cultured on Poly (Ethylene Terephthalate) Nanofibre Scaffolds
J. Patient, K Harris, B Abrahamsson , C Tannergren, A Ghaemaghammi, P Williams, C Roberts, L White, FRAJ Rose

I-4-166
New BEST - biomaterials enhanced simulation test
M. Gasik

I-4-172
An in vitro ocular test system for a detailed quantification of the cellular damage in the corneal epithelium and stroma
M. Bartok, D. Gabel, M. Zorn-Kruppa, M. Engelke

I-4-173
The initial depth of injury in 3-dimensional tissue models for the prediction of the eye-irritation potential of chemicals
M. Zorn-Kruppa, M. Bartok, M. Engelke, K. R. Mewes, K. Daton, K. Reisinger, J. M. Brandner

I-4-186
A 3D Culture System for Investigating Inflammatory Responses in Human Lung
S. S. Htwe, H. Harrington, J. W. Haycock, J. Aylott, A. M. Ghaemmaghami

I-4-204
A new 3D human airway tissue model for in vitro lung cancer research (OncoCilAir™)
C. Mas, S. Huang, L. Wiszniewski, S. Constant

I-4-211
A novel 3d-culture system activating hepatic function of HepG2 cells utilizing a collagen vitrigel membrane chamber and its application to liver metabolism and toxicity test
A. Oshikata-Miyazaki, S. Ishida, T. Takezawa

I-4-235
Offbeat to mainstream: high-throughput, user-friendly three-dimensional cell culture models of brain tumors
D. Ivanov, C. Alexander, D. Walker, T. Parker, P. Gellert, M. Ashford, M. Garnett

I-4-335
Human and rat neuronal microtissues for toxicity testing
J. M. Kelm, D. Fluri, R. Marchan, J. G. Hengstler

I-4-352
Human organotypic nasal epithelial tissue culture as an in vitro model to evaluate effects of cigarette smoke
M. Cabanski, C. Mathis, S. Frentzel, D. Kuehn, S. Majeed, C. Merg , M. Geertz , E. Guedj, R. Dulize, D. Peric, K. Trivedi, A. Benyagoub, Y. Xiang, F. Martin, P. Leroy, N. V. Ivanov, M. C. Peitsch, J. Hoeng

I-4-368
Pre-validation of the Hen´s Egg Test for Micronucleus-Induction (HET-MN): Final evaluation of data
K. Reisinger, D. Fieblinger, A. Heppenheimer, J. Kreutz, M. Liebsch, K. Maul, R. Pirow, A. Poth, P. Strauch, T. Wolf

I-4-369
3D Skin Comet assay: Status quo of the ongoing validation
K. Reisinger M. Bartel, V. Blatz, J. Brinkmann, T. R. Downs, U. Engels, A. Fischer, F. Henkler, S. Hoffmann, S. Jeschke, C. Krul, M. Liebsch, A. Luch, R. Pirow, A. Reus, M. Schulz, S. Pfuhler

I-4-381
Development of an immune-competent model of human upper airway epithelium
W. Aldajani, F. Salazar, H. Harrington, A. Ghaemmaghami

I-4-392
Effect of ATP suppliers on viability of cryopreserved cells
A. Jamshidzadeh, M. Nematizadeh, H. Niknahad, M, Hosseinaghdaie

I-4-397
Global proteomic analysis of acetaminophen toxicity in 3D human liver microtissues
C. Escher, R. Ossola, P. Gunness, M. Bober, F. Grimm, L. Reiter, Y. Butscheid, J. M. Kelm, S. Messner

I-4-418
Biological assay device of neurologic cells with in situ observable gel culture system composed of ECM-modelized matrix
H. Mizumachi, Y. Harada, H. Ijima

I-4-456
The evaluation of spheroid culture of human hepatocytes for drug induced hepatotoxicity
M. Motoi-Ohtsuji, D. Nagai, M. Kakiki, J. Katagi, N. Matsumoto, S. Kaneda, H. Iwai, T. Nagao, T. Ikeya, E. Ozeki, T. Jomura, S. Tanaka, K. Yahiro, T. Tamura, T. Ueda, K. Naitoh, S. Maruya, K. Wada, T. Ohkura, K. Kusumoto, Y. Inoue, H. Arakawa, T. Ogihara

I-4-469
In vitro 3D scaffold-free osteoarthritis model - multiple application options
A. Lang, J. Neuhaus, D. Barnewitz, I. Ponomarev

I-4-550
Human cell-based functional 3D-angiogenesis test for identification of inhibitors of angiogenesis
T. Toimela, O. Huttala, J-R. Sarkanen, T. Heinonen

I-4-722
Evaluation of human hepatocytes cultured by three-dimensional spheroid systems for drug metabolism
H. Arakawa, T. Ohkura, K. Ohta, T. Nagao, K. Kusumoto, A. Koeda, T. Ueda, T. Jomura, T. Ikeya, E. Ozeki, K. Naitoh, Y. Inoue, N. Takahashi, H. Iwai, T. Ogihara

I-4-738
In vitro human alveolar tissue model for pulmonary drug delivery and toxicology applications
P. J. Hayden, G. R. Jackson, J. Oldach, C. Mankus, S. Ayehunie, M. Klausner, H. Kandarova

I-4-776
Importance of reproducibility demonstration of the bio-engineered tissue models used for in vitro toxicity testing purposes
S. Letasiova, M. Bachelor, H. Kandarova, K. Sebova, P. Kearney, M. Klausner

I-4-778
Reconstructed 3-D human small intestinal tissue to assess drug safety, inflammation, and restitution
S. Ayehunie, Z.Stevens, T.Landry, M. Klausner , P. Hayden

I-4-803
LUHMES 3D neuronal model for (developmental) neurotoxicity testing
L. Smirnova, G. Harris, H. Hogberg, D. Pamies, L. Zhao, R. Bachinski, J. Bressler, J. Delp, M. Leist, T. Hartung

I-4-834
A human iPSC-derived 3D model for the assessment of gene/environment interactions during neurodevelopment
G. Harris, D. Pamies, J. Bressler, M. Palma-Lima, L. Smirnova, K. Block, K. M. Christian, C. Zhang, T. Hartung, H. Hogberg

I-4-847
Using human organotypic tissue slices in cancer research
F. Merz, S. Kallendrusch, M. Gerlach, N. Schopow, J. Koerfer, S. Hoebel, A. Aigner, F. Gaunitz, I. Bechmann

I-4-858
The importance of normalization and standardization of cytotoxicity assays for 3D cell models
R. Bachinski, T. Hartung, J. M. Granjeiro, G. G. Alves, H. Hogberg

I-4-859
BIOMEMS for accurate in vivo - in vitro correlation
S.Angeloni Suter

I-4-865
Development of a New Reconstituted Human Oral Mucosal Model to Assess the Oral Irritation Testing
S. Lee, H. Jung, S. Kim

Session I-5: Bioreactors

I-5-271
Rapid fabrication of engineered liver tissue using novel fibroblast system
Y. Sakai, M. Koike, H. Hasegawa, K. Yamanouchi, A. Soyama, M. Hidaka, M. Takatsuki, T. Kuroki, T. Okano, S. Eguchi

I-5-298
Human Fibroblast Remodelling When Cultured In 3D And Under Flow
H. Harrington, S. Ahmed, S.S.Htwe, P.Cato, F. Rose, M.Wilkinson, J. Aylott, A. M. Ghaemmaghami

I-5-336
Engineering hepatic tissues with perfusable vascular structures
T. Osaki , N. Teshima, T. Kageyama, J. Enomoto, J. Fukuda

I-5-420
Protection from Cell Death in Multicellular Spheroids
W. Motoyama, S. Aoki, N. Kojima

I-5-427
Development of a perfusion chamber for the cultivation of 3D skin constructs
K. Struever, F. Gorreja, W. Friess, S. Küchler

I-5-498
2D and 3D human liver cell bioreactors for long-term repeated-dose toxicity testing as a basis for computer-aided prediction
E. Heinzle, F. Noor, S. Klein, M.Ingelman-Sundberg, A. van Dorsselar, C. Chesné, P. Peters, J. Bucher, J. Hengstler, D. Drasdo

I-5-706
The need of innovative technologies for new 3D relevant in-vitro models and the answer of Ivtech
T. Sbrana, G. Mattei, S. Giusti, A. Ahluwalia

I-5-747
Improving in vitro tests of orthopedic implant materials
M. Giazzon, P. Schneider, M. Favre, A. Meister, M. Liley

I-5-780
Bioengineering approaches for the development of novel 3D in vitro models for pre-clinical applications
S. P. Rebelo, D. Simão, C. Correia, A. Terrasso, C. Pinto, R. Costa, M. Serra, C. Brito, P. M. Alves

I-5-805
Use of dynamic 3D primary hepatocyte culture to understand the effects of constitutive androstane receptor activators in primary rat and human hepatocytes
R. Maclennan, A. Bennett, R. Currie

I-5-814
Dose metric considerations of cationic and anionic surfactants in in vitro cytotoxicity assays
N. I. Kramer, S. T. J. Droge, J. J. H. Haftka, E. Opsahl, A. Zwartsen, F. A. Groothuis, B. Nicol, B. J. Blaauboer

Session I-7: Monitoring (telemetry)

I-7-033
Dual pressure telemetry in rats; measuring interventricular asynchrony in experimental pulmonary hypertension
I. Schalij, M. A. de Raaf, W. J. van der Laarse, H. J. Bogaard, M. L. Handoko, A. Vonk Noordegraaf, K. Kramer

I-7-220
Enhanced monitoring of disease studies involving laboratory mice using radiofrequency identification technology
C. A. Richardson

I-7-325
Correlation of infrared thermography vs. rectal body temperature measurements in baboons (papio spp.)
R. Sullivan, N. Schlabritz-Loutsevitch, T. Mandrell

I-7-734
Development of the mCM – mobile circulatory module – for ex-vivo physiological lung tissue for breathing simulation
M. Forjan, M. Frohner

 

Theme II – Predictive Toxicology

Session II-1: Pathways approaches in toxicology

II-1-103
In vitro skin sensitization testing strategy - in-house post-validation with “real-life” compounds
K. Guth, S. Kolle, N. Honarvar, B. Wareing, A. Mehling, B. van Ravenzwaay, R. Landsiedel

II-1-183
Developing a Mitochondrial Toxicity Pathway-Based Non-Animal Approach for Chemical Safety Assessment
J. Li, H. Yuan, T. Zhang, J. Guo, S. Peng, D. Suarez-Rodriguez, A. While, P. Carmichael, C. Westmoreland

II-1-285
Development of an alternative testing strategy for the Fish Early Life-Stage (FELS) test: results of the AOP ‘Acetylcholinesterase inhibition leading to motor activity impairment’
S. Verstraelen, P. Berckmans, L. Vergauwen, R. Blust, F. Dardenne, D. Villeneuve, G. Ankley, D. Knapen, H. Witters

II-1-289
An adverse outcome pathway based approach to evaluate novel tobacco products and electronic nicotine delivery devices in vitro
F. Lowe, K. McQuillan, A. Bushby, G. Phillips, D. Breheny

II-1-432
Identification of cornifelin and early gene response-1 as new biomarkers for in vitro eye irritation using a 3D reconstructed human cornea model, MCTT HCE™
S. H. Choi, M. R. Lee, Y. J. Chun, K. M. Lim

II-1-501
Application of Alternative Toxicity Test Methods for Safety Assessment of Active Pharmaceutical Ingredient Intermediates
M. Múčková, M. Bednáriková, J. Lazová, V. Šmahovský, I. Kakalík

II-1-563
C24:1-ceramide may be a novel lipid biomarker for eye irritation in 3D human corneal epithelial model, MCTT HCE™
M. Lee, S. Choi, K.-M. Joo, Y.-J. Chun, K.-M. Lim

II-1-781
Using Adverse Outcome Pathways for Regulatory Applications
C. E. Willett, P. Antczak, L. Burgoon, F. Falciani, S. Gutsell, G. Hodges, A. Kienzler, D. Knapen, M. McBride, E. J Perkins

II-1-830
The Experience of using the alternative in vitro methods for testing and safety assessment of goods for children, detergents, cosmetics, including raw nanomaterials
N. Zavyalov, Е. Skvortsova, O.Guskova

Session II-2: Systems biology

II-2-095
Enlightening the intracellular metabolic phenotype of neuronal cells: prospects of transient isotope tracer experiments
S. Niedenführ, K. Nöh

II-2-518
Chemical grouping and read across: a biology based approach using metabolomics
B. van Ravenzwaay, M. Herold, H. Kamp, E. Fabian, G. Krennrich, R. Looser, W. Mellert, G. A. Montoya, E. Peter, V.A. Prokoudine

II-2-927
A ToxBank Integrated Data Analysis of SEURAT-1 Reference Compounds
B. Hardy, G. Myatt, P. Kohonen, R. Grafström

Session II-3: Computational modeling and chem-informatics

II-3-074
Inhibition screen of OATP1B1, OATP1B1*15 and OATP1B3 combined with computational modeling to predict OATP-mediated drug-drug interactions
J. Venhorst, E. van de Steeg, H.T. Jansen, I.H.G. Nooijen, J. DeGroot, H.M. Wortelboer, M.L.H. Vlaming

II-3-127
Development of a curated database of in vivo estrogenic activity
P. Ceger, N. Kleinstreuer, X. Chang, B. Jones, J. Hamm, L. Rinckel, D. Rotroff, J. Strickland, W. Casey, D. Allen

II-3-131
Prediction of physicochemical properties of environmental chemicals using molecular fingerprints and machine learning methods
Q. Zang, K. Mansouri, D. Allen, W. Casey, R. Judson

II-3-279
Computational approaches for predicting protein targets for chemical toxins based on molecular similarity and inverse docking
Y. Chushak, J. Schlager , D.Mattie , J. Gearhart

II-3-300
QSAR analysis of human skin sensitization potencies
E. Muratov, V. Alves, D. Fourches, J. Strickland, N. Kleinstreuer, C. Andrade, A. Tropsha

II-3-436
Development of in silico (computational) toxicity screening methods
K. Yuta

II-3-505
Issues relating to the availability and standardisation of data for nanomaterials to assist in risk assessment
A.-N. Richarz, R.L. Marchese Robinson , A. Cassano, M.T.D. Cronin

II-3-510
The application of in silico methods for predictions of different toxicological endpoints
M. N. Drwal, P. Banerjee, M. Dunkel, N. Körner, P. Zwicker, M. R. Wettig, B. Haertel, R. Preissner

II-3-526
Applying cheminformatics approaches to support toxicity prediction and safety assessment of chemicals through the development of robust categories
A.-N. Richarz, S.J. Enoch, M.T.D. Cronin, L. Terfloth, C.H. Schwab, C. Yang

II-3-535
Using Adverse Outcome Pathways to support mechanistic in silico modelling: examples with organ level toxicity
M. T. D. Cronin, S.. J. Enoch, J. C. Madden, F. P. Steinmetz, K. P. Przybylak, A.-N. Richarz, C. Yang

II-3-695
Acute oral toxicity modeling accounting for mechanism and toxicological mode of action
D. Nedelcheva, N. Dimitrova, S. Stoeva, A. Detroyer, R. Note, S. Ringeissen, K. Kirilov, S. Dimitrov, O. Mekenyan

II-3-852
A mathematical model for a reproduction-related adverse outcome pathway in fathead minnows (Pimephales promelas)
M. Mayo, K. H. Watanabe, T. Habib, N. Garcia-Reyero, E. J. Perkins

Session II-4: Risk Assessment

II-4-014
Agglomeration influences cytotoxicity of nanovesicle formulations in vitro
M. P. Vinardell, D. R. Nogueira, M. Mitjans

II-4-041
Validation of the Slug Mucosal Irritation test: correlation with clinical data
J. Lenoir, J.P. Remon, E. Adriaens

II-4-113
Animal welfare observations and early toxicologic assessment tools used to improve selection of traditional drug discovery efficacy models
K. R. Sharp, J. E. McDuffie, J. Ma, B. Zimmerman, A. De Smedt, F. Almy, M. Rizzolio, K. Vriens, S. Snook

II-4-144
Use of the zebrafish developmental screen and estimation of internal concentration to assess toxicity
J. Hamm, N. Kleinstreuer, W. Casey, D. Allen, S. Padilla

II-4-146
Leveraging small aquarium fishes to advance understanding of environmentally influenced human disorders and diseases
J. Hamm, W. Casey, M. Behl, D. Hinton, J. Kanungo, S. Kullman, C. Mattingly, A. Planchart, T. Tal, C. Weis

II-4-205
Challenges and opportunities for conducting safety/risk assessments based solely on in vitro data
H. Clewell

II-4-250
In vitro skin corrosion as a pre-validation study of Reconstructed Human Epidermis in house developed
C. Catarino, P. Pennacchi, T. Pedrosa, S. Barros, S. Maria-Engler

II-4-278
Evaluation of immunotoxicity of natural compounds by a combination of functional in-vitro investigation and proteomics
N. Schultze, P. Zwicker, G. Wachlin, M. Drwal, M. Dunkel, M. Lalk, R. Preissner, U. Lindequist, B. Haertel

II-4-331
Integrated test strategy for cosmetics safety and efficacy assessment
S. Cheng, Y. Qin, F. Pan

II-4-343
How to improve the high variability of the in vitro dermal absorption test?
B. Desmedt, P. Courselle, J.O. De Beer, V. Rogiers, E. Deconinck, K. De Paepe

II-4-355
Use of in vitro assays to compare the effects of exposure to smoke and smoke extracts from a conventional cigarette and a reduced toxicant prototype
O. Oke, D. Azzopardi, S. Corke, K. Hewitt, T. Carr, G. Foss-Smith, M. Taylor, K. Patel, F. Lowe

II-4-373
Lentiviral transduction to drive a liver - derived rat epithelial cell line from biliary origin towards hepatocyte-like cells
J. Bolleyn, N. Nair, J. De Kock, M. Chuah, T. VandenDriessche, V. Rogiers, T. Vanhaecke

II-4-398
Optimization of an eye irritation assay for solid materials for hazard identification and labelling of chemicals
Y. Kaluzhny, H. Kandarova, L. d’Argembeau-Thornton , J. De Luca , P. Hayden, A. Hunter, T. Truong, K. Klausner

II-4-443
Risk assessment of consumer products by use of alternative tox methods
M. Deore, A. Patil, D. Bakre, N. Ravishankar

II-4-509
A method proposed to estimate the index of relevance using the statistical imputation approach
M.Endo, T. Omori

II-4-561
Cytotoxic, cytoprotective and genotoxic evaluation of grape pomace extract against hydrogen peroxide insult
L. García-Becerra, M. Mitjans, R. Castro-Ríos, J. Verde-Star, C. Leos-Rivas, C. Rivas-Morales, A. Oranday-Cárdenas, A. Chávez-Montes, P. Vinardell

II-4-577
Isolated intervertebral disc cells as a platform for in vitro toxicology testing
L. Gradisnik, T. Velnar

II-4-650
A review of the REACH legislation from the animal welfare perspective
K. Taylor

II-4-660
Refined animal toxicity testing using unequally sized dose groups and Benchmark Dose analysis
J. Ringblom, F. Kalantari, G. Johanson, M. Öberg

II-4-735
Metabolism simulation and toxicity prediction in the evaluation of food ingredient/contaminant safety
L. Terfloth, K. Arvidson, K. Muldoon-Jacobs, P. Volarath, A. Tarkhov, T. Magdziarz, J. Rathman, D. Hristozov, C. Yang

II-4-763
Comparison of in vitro and in vivo methodologies for eye irritation evaluation of cosmetic formulations
C. A. Brohem, B. B.Swinka, A. C.Weihermann, A. P. M. Canavez, E. L. Rocha, V. M. Di Mambro, O. Kruger, M. Lorencini

II-4-808
Cultured porcine cornea assay using confocal microscopy for high resolution detection and quantification of sub-mild ocular irritation
M. Piehl, M. Carathers, E. Ryan, W. Hahn, D. Cerven, G. DeGeorge

II-4-809
The replacement ocular battery (robatt): an integrated testing strategy for ocular irritation classification
D. Cerven, M. Piehl, M. Carathers, G. DeGeorge

II-4-877
Cytotoxicity and cell adhesion evaluation of chitosan films with herbs actives for burns treatment
B. P. Genesi, P. S. Lopes, C. F. da Silva

Session II-5: Application in decision making and testing strategies

II-5-364
Use of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine permanent hair dyes
C. Obringer, N. Hewitt, J. Manwaring, C. Goebel, H. Rothe

II-5-383
A risk-warning method for reporting adverse events:-An application of Bayesian statistics to the cosmetics industry-
A.Yamashita, T.Omori

II-5-438
Comparison of 3 criteria incorporating variation of index for toxicityof the interleukin 8 luciferase Luc assay (IL-8 Luc assay)
A. Maruya, S. Aiba, Y. Kimura, M. Watanabe, N. Suzuki, K. Saito, Y. Nakajima, Y. Ohmiya, H. Kojima, N. Tanaka

II-5-446
An easy method for estimation of the half-maximal inhibitory concentration using curve fitting appropriate to the concentration-response relationship
A. Mori, N. Suzuki, H. Nagahori, K. Saito, F. Le Coz, M. Kobayashi, A. Maruya, T. Omori

II-5-452
Relationship between IC50 and ID50 value in the Hand1-Luc Embryonic Stem cell Test (Hand1-Luc EST)
M. Kobayashi, N. Suzuki, H. Nagahori, K. Saito, F. Le Coz, A. Mori, A. Maruya, T. Omori

II-5-595
Integrated safety assessment (ISA) of food products
L. van der Geest, H. Bouwmeester, T. Bovee, R. Hoogenboom, E. Kok, A. Peijnenburg

Session II-7: Update from Europe – Alternative testing strategies program

II-7-291
SEURAT-1: Towards Mechanism-based Repeated Dose Systemic Toxicity Testing
M. Schwarz

Session II-8: Meeting new regulatory challenges following the cosmetic ingredients ban – Cosmetics Europe’s research programme on alternatives

II-8-796
In vitro model for assessing impact of mechanical and chemical skin injuries
H. Dabboue, E. Frouin, C. Cardaire, J. Ramos, G. Marti-Mestres

Session II-9: Exposure

II-9-060
Comparison of protocols measuring stratum corneum diffusion/partition coefficients and skin penetration
N. J. Hewitt, R. Cubberley, H. Duplan, J. Eilstein , D. Gerstel, S. Grégoire , C. Jacques-Jamin, M. Klaric, H. Rothe, A. Schepky

II-9-102
Standardized experimental set-up for dermal absorption studies in vitro
K. Guth, E. Fabian, S. Wölk, B. van Ravenzwaay, R. Landsiedel

II-9-338
The Methodology for Evaluating Mucosal Irritation on Human Oral Tissue Model
J. H. Kim, S. A. Cho, J. Y. Choi, J. H. Lee, K. M. Kim, S. An

II-9-385
Development of exposure systems for the in vitro assessment of “heat-not-burn” tobacco and electronic nicotine delivery devices
H. Green, D. Azzopardi

II-9-394
Assessing the skin irritation potential of rinse off personal care products using a reconstructed human epidermis model: exposure time and product dilution impact
F. Lopez, S. Catoire, D. Mora, A. Cano, B. Rodriguez, A. Thelu, A. Josseaume, E. Lambert

II-9-457
AOH Exposure induced oxidative stress in caco-2 cells
C. Fernández-Blanco, G. Font, M. J. Ruiz

II-9-567
Bovine serum albumin binding and toxicity of cationic chemicals in in vitro cell assays
F. A. Groothuis, B. Nicol, B. J. Blaauboer, N. I. Kramer

II-9-687
SDF-1 induced migration of THP-1 cells through a monolayer of human coronary artery endothelial cells promotes differentiation of monocytes to an adhesive phenotype
M. Van der Toorn, S. Frentzel, M. Peitsch, J. Hoeng, H. De Leon

II-9-692
Overcoming the barriers to the uptake of microsampling techniques in regulatory safety studies
S. Jackson

II-9-850
Retrospective analysis on the correlation between cytokine release from a 3D keratinocytes tissue model and clinical human ocular response to mild surfactant systems
R. M. Walters, E. Bruning, L. Fakhrzadeh, C. Mack Correa, E. Atillasoy, K. Martin, J. R. Nash, N. Wilt, G.-E. Costin, H. A. Raabe

Session II-10: Topical toxicity

II-10-068
Digging between photoallergenic or photoirritant behaviour with the RBC-PT
M. Mitjans, M. P. Vinardell

II-10-099
Additional joint research on eye irritation alternative method with human corneal model; LabCyte CORNEA-MODEL24
H. Ikeda, M. Katoh, T. Omori, A. Yamashita, M. Endo, S. Shinoda, S. Hagiwara, T. Kasahara, H. Tahara, S. Nakahara, S. Akiyama, Y. Yoshitake, H. Kojima

II-10-187
Advantage of “Vitrigel-EIT (eye irritancy test) method”: A brief eye irritation test utilizing changes of barrier function after exposing chemicals to a human corneal epithelium model as an indicator
H. Yamaguchi, H. Kojima, T. Takezawa

II-10-193
Assessment of in vitro eye irritation – testing strategy
K. Tegethoff, H.-W. Vohr, G. Stropp

II-10-206
Further refinements of IRR-IS®, an Episkin® based model for quantifying chemical irritation potency
F. Cottrez, E. Boitel, H. Groux

II-10-233
New evaluation method for skin irritation of oil-soluble chemicals with monolayer culture system
N. Imai, Y. Goto, S. Nomura, T. Masunaga

II-10-239
SkinEthic RHE method categorises chemicals between corrosive subcategories and non-corrosive as stated in OECD TG431
N. Alépée, C. Tornier, J. Cotovio

II-10-241
In vitro skin corrosion and irritation assessment of ingredients using EpiSkin methods: Sequential Top-Down and Bottom-Up approaches
N. Alépée, M.H. Grandidier, J. Cotovio

II-10-242
Integrated approach for skin corrosion and skin irritation using in vitro SkinEthic RHE test methods
N. Alépée , M.H. Grandidier, J. Cotovio

II-10-261
Development of a testing strategy to evaluate 24 h-exposure skin irritation using OECD TG439 and new monolayer culture system
S. Nomura, Y. Goto, N. Imai, T. Masunaga

II-10-266
Modification of 3T3 NRU photo-toxicity test conditions for the evaluation of poorly water-soluble substances
A. Toyoda, M. Sugiyama, S. Furihata, K. Nishizumi, H. Itagaki

II-10-294
Cytotoxicity, phototoxicity and genotoxicity evaluation of sucupira oil: a potential new cosmetic ingredient
M. T. Uemura, E. A. Ostroky, M. B. Mathor, N. Andreo-Filho, T. M. Kaneko, D. P. Luco, M. T. F. Bara, J. R. Paula, P. S.Lopes

II-10-332
Integrated CAMVA and BCOP methods to predict eye irritation of cosmetics
Y. Qin, S. Cheng

II-10-441
Comparison of mouse primary hepatocyte spheroids formation on Cell-ableTM plates with various feeder cells
S. Wakuri, R. Saito, K. Sasaki, M. Gondo, N. Endo, H. Sui, K.Yamakage

II-10-448
Introduction of 3D methods for regulatory testing and research in NICS
Zs. Bartos, Z. Forgacs, M. Szivos-Racz, J. Major

II-10-495
Predicting eye stinging using the novel NociOcular assay
L. Krawiec, K. Norman, R. Curren, Forsby, A.

II-10-587
Observations on the use of the bovine corneal opacity and permeability (BCOP) assay to evaluate the eye irritation potential of prototype cosmetic formulations containing salicylic acid, glycolic acid and ethanol
R. Labib, E. Gilberti, G.-E. Costin, D. Gossai, H. Raabe, S. Gettings

II-10-636
Suitability of histopathology as an additional endpoint to the Isolated Chicken Eye test for classification of non-extreme pH detergent and cleaning products
E. Cazelle, C. Eskes, M. Hermann, P. Jones, P. McNamee, M. Prinsen, H. Taylor, M. Wijnands

II-10-637
Tiered approach to the use of alternatives to animal testing for evaluation of eye irritation potential of cosmetic ingredients: hair dye case study
P. McNamee, G. vonBoelcshazy, C. Goebel

II-10-638
The importance of understanding drivers of irritation in vivo for selection of chemicals used in the development and evaluation of in vitro serious eye damage/eye irritation assays: Cosmetics Europe analysis
P. McNamee, N. Alépée, J. Barroso, A De Smedt, B. De Wever, J. Hibatallah, M. Klaric, K. Mewes, M. Millet, U. Pfannenbecker, M. Tailhardat, M. Templier

II-10-714
Skin irritation potential of UV-filters and vitamin A using a full-thickness reconstructed skin model
C. G. Benevenuto, P. C. Pennacchi, A. C. Fruet, S. S. Maria-Engler, L. R. Gaspar

II-10-774
Exploring of new alternative test method for phototoxicity in ophthalmic agent using SIRC cell lines and 3D human reconstituted cornea models
S. Y. Kim, M.-H. Nam, J.-Y. Yun, J. S. Lee, I. Y. Ahn, J. H. Lee, K. H. Choi

II-10-868
Use of ECVAM validated EpiDerm skin corrosion test (EpiDerm SCT) for sub-categorization according to the UN GHS
H. Kandarova, S. Letasiova, T. Milasova, P. Hayden, M. Klausner

II-10-869
Identifying the appropriate protocol for testing surfactants and surfactant-based formulations in the bovine corneal opacity and permeability assay
J. E. Bader, K. G. Norman, H. A. Raabe

II-10-874
Performance of the chorion-allantoic membrane stained by trypan blue (CAM-TBS) of different concentrations of surfactant sodium dodecyl sulfate (SDS) for assessing the eye irritation potential
R. Silva, V. Ribeiro, C. Caldeira, O. Presgrave, I. Delgado

II-10-936
Reconstructed Human Epidermis Test Methods for Skin Corrosion Endpoint: How Can Changes in Prediction Models Improve Final Predictions?
B. Desprez, J. Barroso, C. Griesinger, H. Kandarova, N. Alépée, H. Fuchs

II-10-951
NativeSkin – a standardized ex vivo skin system to predict human skin responses
S. Kurdykowski, A. A. David, C. A. M. Jardet, P. Descargues

 

Session II-11: Repeated dose toxicity

II-11-270
Pharmacokinetics of serum honokiol with oral administration Magnolia ethanolic extract in Sprague-Dawley rats
Y.-J. Tsai , J.-S. Huang, P.-Y. Tsai, C.-J. Yao, L.-Y. Kuan, H.-L. Chen, T.-Y. Lai, G.-M. Lai, J. Whang-Peng, J.-M. Chang

II-11-529
Do we still need the 2-year rat carcinogenicity study?
C. Krul, R. Woutersen, A. Soffers, D. Kroese, M. Luijten, J. van Benthem

II-11-818
Developing an integrative approach for predicting acute oral toxicity: Lessons learned
R. Note, D. Blanchet, J. Clouzeau, A. Detroyer, D. Duché, L. Le Capitaine, H. Noçairi, G. Ouédraogo, S. Ringeissen, S. Teissier

II-11-819
An integrative approach for the prediction of acute oral toxicity: Past and future
R. Note, H. Noçairi, D. Blanchet, C. Gomes, G. Ouédraogo, S. Teissier, F. Leroy, J. Cotovio

Session II-12: Skin sensitization

II-12-027
Development of a new local lymph node assay that evaluates the elicitation response
K. Yamashita, S. Shinoda, S. Hagiwara, H. Itagaki

II-12-047
An inter-laboratory validation study of IL-8 Luc assay using a stable THP-1-derived IL-8 reporter cell line, THP-G8
Y. Kimura, M. Watanabe, N. Suzuki, K. Saito, Y. Nakajima, Y. Ohmiya, T. Omori, H. Kojima, N. Tanaka, S. Aiba

II-12-048
A dataset on 80 chemicals tested by IL-8 Luc assay
Y. Kimura, C. Fujimura, S. Aiba

II-12-078
Investigation of the use of THP-1 cells and IL-8 release to assess water-insoluble chemicals with the Short Time Exposure test method
K. Narita, H. Kojima, H. Itagaki

II-12-080
EURL ECVAM validation study on skin sensitisation test methods
S. Casati, P. Aeby, A. Angers-Loustau , D. Basketter, T. Cole, S. Hoffmann, J. Richmond

II-12-110
LLNA variability: an essential ingredient for a comprehensive assessment of non-animal skin sensitisation test methods and strategies
S. Hoffmann

II-12-112
Inter-laboratory validation of an in vitro method to classify skin sensitizers
A. J. Clippinger, D. J. Keller, III, J. M. McKim, Jr, H. Witters, A. R. Van Rompay

II-12-132
Predicting skin sensitization using 21st century toxicology
N. Kleinstreuer, J. Strickland, W. Casey

II-12-134
Development of an open-source integrated testing strategy for skin sensitization potency
J. Pirone, M. Smith, N. Kleinstreuer, T. Burns, J. Strickland, Y. Dancik, R. Morris, W. Casey, J. Jaworska, D. Allen

II-12-177
THP-1 assay predicts allergenic potential of chemicals in accordance with ratings given by LLNA and patch tests
C. B. Parise, V. M. Sá-Rocha, J. Z. Moraes

II-12-180
Modelling the skin sensitisation Adverse Outcome Pathway (AOP) for risk assessment
N. Gellatly, R. Cubberley, S. Dhadra, S. Jacquoilleot, G. Maxwell, C. Moore, R. Pendlington, J. Pickles, O. Saib, D. Sheffield, R. Stark, V. Summerfield, C. Mackay

II-12-191
Skin sensitisation EPAA/CEFIC LRI activities progressing non-animal testing strategies
A. Mehling, D. Basketter, J. Crozier, B. Hubesch, I. Manou

II-12-221
Improving dendritic cell-based skin sensitization assays by integrating tolerogenic markers
C. van Helt, S.F. Martin, H. Wenck, A. Schepky, J. Kühnl

II-12-245
Skin sensitization prediction: transferability and reproducibility of the MUSST
C. Piroird, L. Nardelli, M.Aujoulat, A. Hohenstein, N. Pearson, N. Alépée

II-12-259
Techniques for efficient isolation of human Langerhans cells: assessment of potential allergenic compounds
D. P. Luco, D. Steffens, P. S. Lopes, M. T. Uemura, M. B. Mathor

II-12-280
International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity
M. A. T. Teunis, S.W. Spiekstra, M. Smits, E. Adriaens, R. Landsiedel, R. Pieters, V. Galbiati, E. Roggen, E. Corsini, S. Gibbs

II-12-323
Evaluation of the direct peptide reactivity assay (DPRA) in identifying epoxy resins with skin sensitizing potential
C. L. Wong, A. L. Lam, S. Ghassabian, M. T. Smith

II-12-326
Photo-safety assessment using multiple in vitro tests
S. Oeda, H. Nishida, M. Hirota, T. Ashikaga, H. Kouzuki, S. Onoue, S. Aiba, Y. Tokura

II-12-346
In-house validation and technology transfer of the GARD assay for the prediction of sensitizing compounds
K. S. Zeller, A. Forreryd, H. Johansson, F. Rydnert, A.-S. Albrekt, C.A.K. Borrebaeck , M. Lindstedt

II-12-348
Development of skin sensitization test method using THP-1 cells cultured on a collagen vitrigel membrane chamber for oily materials
T. Uchino, H. Miyazaki, K. Yamashita, H. Kojima, A. Oshikata-Miyazaki, T. Takezawa, K. Shimizu, T. Akiyama, Y. Ikarashi

II-12-358
Relationship of contact allergen potency and size of the T cell pool and T cell receptor repertoire
P. R. Esser, M. Huber, A. Kolberg, M. Klaric, E. Bachtanian, K. Reichenbach, V. Weber, S. F. Martin

II-12-366
Application of the reconstructed human epidermis model, Keraskin™, for identifying skin sensitizer
W. H. Jang, G. Choi, K. M. Jung, S. A. Cho, S. An, S. H. Seok, Y. Heo, M. Y. Park

II-12-380
Optimisation of the human T Cell Priming Assay for the identification of chemical allergens
V. Mutez, M. Vocanson, P. Esser, M. Klaric, St. Martin, J. F. Nicolas

II-12-387
Performance standards for local lymph node assay: 5-bromo-2-deoxyuridine-flow cytometry method (LLNA: BrdU-FCM) for skin sensitization alternatives
Y. Heo, K-W. Yeo, J-H. Jo, W-H. Jang, M-Y. Park, K-M. Lim, M-S. Jung, E-Y. Jeon

II-12-451
Analysis of in chemico and in silico methods to predict skin sensitization potentials
D. Urbisch, A. Mehling, S. N. Kolle, N. Honarvar, W. teubner, K. Guth, R. Landsiedel

II-12-543
LuSens: a novel reporter gene-cell line to identify skin sensitizers
T. Ramirez, A. Mehling, A. Aumann, T. Eltze, S. Kolle, D. Urbisch, W. Teubner, C. Wruck, R. Landsiedel, B. van Ravenzwaay

II-12-549
Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes
V. Galbiati, A. Papale, C. L. Galli, M. Marinovich, E. Corsini

II-12-559
Variability in data from skin sensitization and reactivity testings
H. Ivanova, A. Detroyer, C. Piroird, C. Gomes, J. Eilstein, I. Popova, C. Kuseva, Y. Karakolev, S. Dimitrov, O. Mekenyan

II-12-594
Epidermal Sensitization Assay (EpiSensA) with reconstructed human epidermis for detecting sensitizing potential of lipophilic chemicals
O. Takenouchi, K. Saito, Y. Nukada, M. Miyazawa, H. Sakaguchi

II-12-680
Estimation of the skin sensitizing potency based on peptide reactivity, dendritic cell activation and read-across using the hair dye 2-methoxymethyl-paraphenylenediamine as example
C. Goebel, J. A. Troutman, J. Hennen, H. Rothe, H.Schlatter, G. F. Gerberick, B. Blömeke

II-12-710
In vitro skin sensitization methods: evaluating the available reference datasets
J. F. Lalko

II-12-716
Development of improved skin sensitization assays based on 3D reconstructed human epidermal equivalents and secreted luciferase reporter activity
P. J. Hayden, M. Miyazawa, P. Lei, C. Mankus, O. Takenouchi, K. Saito, G. R. Jackson, S. T. Andreadis, Y. Ohmiya, H. Sakaguchi

II-12-725
Evaluation of SENS-IS®, an Episkin® based model for identifying chemical sensitizers of fragrance ingredients
A. Del Bufalo, F. Tourneix, S. Martinozzi-Teissier, F. Cottrez, H. Groux, J. Cotovio

II-12-742
IL-18 secretion as a marker for identification of contact sensitizers in the EpiDerm™ in vitro human skin model
J. Oldach, S. Letasiova, H. Kandarova, M. Klausner, P. J. Hayden

II-12-779
Refinement of the peroxidase peptide reactivity assay (PPRA) and prediction model
J. A. Troutman, C. Goebel, H. J. Dai, R. L. M. Dobson, M. Quijano, G. F. Gerberick

II-12-786
A dermal sensitization assay using SkinEthic™ RHE
G. DeGeorge, M. Troese

II-12-801
A highly differentiated 3d epidermal skin model to characterize skin sensitizers
L. Pratt, M. Troese, G. DeGeorge

II-12-802
Implementation of the RHE / IL-18 sensitization assay – Accuracy, sensitivity and specificity evaluation
E. Andres, J. De Brito, A. Hundt, E. L. Roggen, C. Dini, P. J. Ferret

II-12-833
Co-culture assay for the identification and investigation of dermal sensitizers (epi-dc)
G. DeGeorge, M. Troese, L. Pratt , M. Piehl, P. Hayden, S. Ayehunie

II-12-841
Probabilistic Hazard Assessment for Skin Sensitization Potency using Machine Learning to Design Integrated Testing Strategies
V. Rocha, T. Luechtefeld, A. Maertens, A. Kleensang,, T. Hartung

Session II-13: Endocrine disruption

II-13-128
Performance of the BG1Luc and ER beta-lactamase estrogen receptor transactivation assays in Tox21 compound screening
W. Casey, R. Huang, J-H. Hsieh, K. Shockley, S. Sakamuru, M. Xia, R. Tice, L. Rinckel, P. Ceger, D. Allen

II-13-129
Development of reverse toxicokinetic models to correlate in vitro and in vivo estrogen receptor activity
X. Chang, N. Kleinstreuer, P. Ceger, J-H. Hsieh, J. Hamm, B. Jones, N. Choksi, L. Rinckel, D. Allen, W. Casey

II-13-136
Targeted testing of FXR Tox21 active compounds
J. Hamm, W. Casey, C. Hsu, K. Houck, X. Chang, D. Allen, S. Kullman

II-13-329
An Inter-laboratory validation study of an androgen receptor stably transfected transcriptional activation (AR STTA) assay for a new OECD test guideline
A. Ono, M. Takeyoshi, Y. Maeda, N. Suzuki, H. Kojima, S. Takeuchi, J. H. Hong, H. S. Lee, A. M. Vinggaard, J. Odum, S. Laws, H. Kojima

II-13-482
New biomarkers for endocrine disruption evaluation on microplate using a human placental cell line
A. Wakx, T. Fournier, P. Rat

II-13-611
Estimation of estrogen receptor binding affinity by QSAR approach
M. Rucki, H. Bendová, J. Sosnovcová

Session II-14: Reproductive & developmental toxicology

II-14-038
In vitro cytotoxicity assessment of a trichotecene mycotoxin T-2 toxin on SerW3 cells
E. Karacaoğlu, G. Selmanoğlu

II-14-164
Development of alternative tests for reproductive and developmental toxicity: whole embryo culture in humanized CYP3A (CYP3A-HAC) mice
M. Akita, Y. Kazuki, S. Abe, N. Ishizuka, A. Yokoyama, T. Kamataki, M. Oshimura

II-14-215
Acrylamide and Its Metabolite Glycidamide can Effect Antioxidant System and Steroidogenesis in Leydig Cell in vitro
Y. Tunali, M. Erkan

II-14-216
Effects of Acrylamide and Glycidamide on Antioxidant Systems and Steroidogenic Enzymes on TM4 Sertoli Cell
Y. Tunali

II-14-217
Acrylamide and Glycidamide can Effect Leydig and Sertoli Cell Viability, Oxidative Damage and Apoptosis in vitro
B. Orta-Yilmaz, N. Yildizbayrak, M. Erkan

II-14-262
Development of in vitro detecting method for developmental toxicity using mouse embryonic stem cells - Hand1-Luc Embryonic Stem cell Test
N. Suzuki, F. Le Coz, H. Nagahori, K. Saito

II-14-357
Express assessment of geno-, cyto- and embryotoxic effects of potential teratogens using an integrated in vitro test-system based on rat whole embryo culture
I. Strekalovskiy, L. Shabasheva, V. Popov, Y. Panfyorova

II-14-513
Toward validation of a human in vitro assay for developmental toxicity assessment
L. Egnash, K. Conard, J. Palmer, A. Smith, P. West, R. Burrier, E. Donley, F. Kirchner

II-14-548
Using Cellular Signals to Assess Developmental Toxicity of Compounds in a Mouse Embryonic Stem Cell System
M. A. T. Teunis, S. Verkoeijen, P. Mika, K. Lai, P. T. Theunissen, A. H. Piersma, C. A. M. Krul

II-14-748
New in vitro method to image and quantify neural cell migration
P. Salonen, T.Toimela, J. Kreutzer, P. Kallio, T. Heinonen, A. Price, T. Ylikomi

Session II-15: Genotoxicity/Carcinogenicity

II-15-086
Evaluation of potential carcinogenic effects of SiO2 nanoparticles in human lymphocyte culture using genetic and functional markers
I. Kolesnikova

II-15-154
Genotoxic evaluation of essential oils: comparison between classical and automated micronucleous in vitro assay
N. M. Esteves-Pedro, P. S. Lopes, M. B. Mathor, D. Perez, R. Albuquerque, P. H. Moreno , T. M. Kaneko

II-15-287
Hydra as a small animal model for environmental toxicity testing: standardization of comet assay
A. Murugadas, Md. Zeeshan, P. Balaji, P. C. Vinodha, K. Thamaraiselvi, M. A. Akbarsha

II-15-320
The use of SHE cell transformation assay to predict the transforming potential of non genotoxic carcinogens
A. Colacci, M. Vaccari, M. G. Mascolo, S. Perdichizzi, C. Zanzi, F. Rotondo, C. Parfett, R. Corvi, S. Grilli

II-15-463
A new resource for predictive toxicology: EURL ECVAM genotoxicity and carcinogenicity database of positive Ames test chemicals
R. Corvi, F. Madia, A. Worth, M. Whelan

II-15-527
Reduction of misleading (“False”) positive results in mammalian cell genotoxicity assays and its favourable impact on animal use
P. Fowler, K. Williams, L. Jeffrey, J. Young, N.J. Hewitt, R. Fautz, D. Kirkland, P. Carmichael, P. Pfuhler

II-15-552
Development of a method to compare genotoxic hazard of water samples
A. R. Van Rompay, B. Martijn, S. Verstraelen, E. J. M Penders, P. K. Baggelaar

II-15-591
In vitro cytotoxicity and genotoxicity testing using upcyte hepatocytes
A. Noerenberg, V. Sonntag-Buck, N.J. Hewitt, S. Heinz, J. Braspenning

II-15-702
In vitro immunotoxicity screening of xenobiotics using human lymphoblastoid cell lines
T. Markovic, M. Gobec, D. Gurwitz, I. Mlinarič-Raščan

II-15-767
Investigation of the genotoxic potential of a new Brazilian botanical extract – a case study
C. Zacarias, A. Armelini, K. Lucena, K. Arroteia, P. Araujo, K. Assanome, D. Pedroso

II-15-855
RSMN (Reconstructed Skin Micronucleus Assay): Update on the ongoing validation
S. Pfuhler, M. Aardema, B. Barnett, E. Costin, S. Hoffmann, G. Mun, G. Ouedraogo, S. Roy, R. Curren

II-15-955
The Automated FADU-Assay to Quantify Formation and Repair of DNA Strand Breaks – A Rapid and Meaningful Genotoxicity Quantification
M. Pilartz, M. Unger, M. Moreno-Villanueva, I. Pfitzner

Session II-16: Inhalation toxicology

II-16-067
Prototype inhalation risk assessment for biopersistents using adverse outcome pathway (AOP) approaches
P. Jones, B. Bradford, P. Fowler, A. Furniss, A. Homan, R. Stark, A White

II-16-163
The use of a Long Shelf-life 3D Model of the Human Airway Epithelium (MucilAir™) for acute and repeated dose Respiratory toxicity assessment
S. Constant, S. Huang, L. Wiszniewski

II-16-273
A technical approach on precise determination of minimal mass of deposited airborne particles
A. Schafmeister, A. Geisszkopf

II-16-302
Fundamental improvements of the air-liquid interface technique for use in in-vitro inhalation toxicology
J. Knebel, D. Ritter, C. Brodbeck

II-16-421
Applicability of rat precision-cut lung slices in evaluating nanomaterial cytotoxicity and inflammation
U. G. Sauer, S. Vogel, A. Aumann, A. Hess, S. N. Kolle, L. Ma-Hock, W. Wohlleben, M. Dammann, V. Strauss, S. Treumann, S. Gröters, K. Wiench, B. van Ravenzwaay, R. Landsiedel

II-16-431
In vitro assessment of airway effects of key products from ozone-initiated oxidation of limonene and printer exhaust
I. Nelissen, F. Maes, A. Jacobs, S. Remy, S. Verstraelen, E. Goelen

II-16-764
The CULTEX® RFS Compact: the next generation of CULTEX® systems for the direct exposure of cells at the air-liquid interface
N. Moehle

Session II-17: Ecotoxicology

II-17-052
Using chlorella kessleri for monitoring of water quality
V. Harvenda, L. Umar, J.Wiest

II-17-093
Strategies to reduce the number of fish used in ecotoxicity tests
G. Stoddart, K. Sullivan

II-17-309
Revisiting Hydra in the wake of vision Tox21
M. Zeeshan, A. Murugadas, M. V. Muhsin, B. R. Ramaswamy, M. A. Akbarsha

II-17-481
Novel in-vitro tests for analysis of indoor environment toxicity correlated to human health
M. Salkinoja-Salonen, M. Gasik, M. A. Andersson, J. Atosuo, A. Hyvärinen, K. Huttunen

 

Theme III – 3Rs in Academia & Education

Session III-1: 3Rs in academic education, training programs and anticipated needs

III-1-072
Survey of Canadian research and teaching institutions on strategies for implementation of the Three Rs
A. Plante, J. Alcorn

III-1-165
Experience in the use of alternatives to animal experimentation in the learning capability of undergraduate students of human physilology at the Universidad de Guadalajara, Centro Universitario de la Costa 2008 to 2014
V. Rojas-Sahagún, S. Viruete-Cisneros, R. Preciado-González, M. Greig, K. Barrios-Pérez, L. Villaseñor-Loeza, J. Esparza-Barajas, A. Delgado-Romero, P. Santiago-Teodoro, N. Mera-Riofrio

III-1-222
An Indian educational initiative to promote the use of alternatives to animal testing with special reference to 3D reconstructed human tissues
A. Riyasdeen, C. Pellevoisin, A. Alonso, M. A. Akbarsha

III-1-263
Continuous education and trainings promotes the 3Rs alternative methods development in China
S. Cheng

III-1-517
Conscientious objection to harmful animal use within veterinary and other biomedical education
A. Knight

III-1-566
An inspiring book telling the personal stories on the Replacement, Reduction and Refinement of laboratory animal use
M. Schilders-van Boxel, I. Toussaint

III-1-576
EPA’s Toxicity Forecaster Research Effort Communications and Outreach Overview
M. Linnenbrink

III-1-609
4-year experience teaching alternative methods to animal use in toxicology
F. Caloni

III-1-627
Graduate training program BB3R
V. Kral, G. Weindl, J. Plendl, H. Fink, B. Kleuser, A. Pries, R. Preissner, A. Luch, G. Schönfelder , R. Lauster, M. Weber, M. Schäfer-Korting

III-1-678
Experiments on Animals: Ideals of Humane Education & Real Practice
I. Merkulova, T. Mishatkina, T. Hlinkina

III-1-708
Нumane alternatives application on biology school lessons for the purposes of eco-ethical thinking formation among youth
L. M. Loginovskaya

III-1-824
Humanising and modernising medical education: Change in the Ukraine
I. Strelchenko , D. Leporsky, N. Jukes

Session III-2: Funding Agencies and Funding Programs

III-2-023
The Danish 3R-Centre
L. B. Broenden , T. Bengtsen, C. L. Nellemann

III-2-208
Motivating synthesis of evidence part of more knowledge with fewer animals programme
E. van Oort, C. Schuttevaer, R. Diemel , U. Gangaram Panday

Session III-3: Innovative teaching and training tools

III-3-119
NORINA: information on animal alternatives in a changing world
K. Smith

III-3-188
Development of the New Korean Teaching Aids on the Three Rs Principles: Translation of “The Three Rs and the Humanity Criterion”
B. I. Choe, G. H. Lee, B. H. Lee, S. Trigwell, M. Balls

III-3-194
Animal alternatives in veterinary teaching- status and scope in an Indian veterinary university
A. B. Jacob, C. Leena, M. R. Saseendranath

III-3-409
Peer mentoring and alternatives to using animals as a strategy for education in the life sciences
A. Meneses-Parga, S. Viruete-Cisneros, Y. De La luz-Esparza, D. López-Grano, P. Gay-Hernández, I. Casillas-Martínez, O. López-Padilla, E. Díaz-Pelayo, M. Martínez-Toscano, R. Preciado-González

III-3-433
Overview of the free virtual experiments - computer simulations for teaching Pharmacology
D. Modun, E. MacDonald

III-3-487
Emphasis on Zoology curriculum based on non-invasive teaching methods of Physiology and Anatomy has significantly reduced the animals use in practical classrooms in India
K. K. Sharma, V. Sharma, N. Sharma, M. A. Akbarsha

III-3-489
Digitization of zoology museums can reduce the number of wild animals sacrificed for teaching of biosystematics: Another dimension to implementation of 3Rs principle in teaching
V. Sharma, K. K. Sharma, N. Sharma, M. A. Akbarsha

III-3-490
Prokaryotes can be used as an effective animal alternative in genotoxicity testing of antifertility and xenobiotic compounds in routine lab courses
N. Sharma, V. Sharma, K. K. Sharma, M. A. Akbarsha

III-3-515
The development of a clinical skills laboratory at Ross University School of Veterinary Medicine
B. Grevemeyer, A. Knight

III-3-564
 ‘Live zoology’ an effective, non-invasive replacement alternative to animal dissections in zoology curriculum
M. C. Sathyanarayana, M. A. Akbarsha

III-3-601
Virtual Physiology: Computer Laboratories for Life Science Education
A. Tchaptchet, J. R. dell‘Oro-Friedl, D. Immer, H. Schneider, T. Braun, H. A. Braun

III-3-626
3Ts teaching touching toxicology in veterinary medicine degree: a project
F. Caloni, L. Müller, C. Cortinovis, M. Balogh

III-3-631
Synthesis of evidence and systematic reviews of animal studies: urgently needed innovations in laboratory animal science education
M. Leenaars, M. Ritskes-Hoitinga

III-3-654
Humane education strategies for veterinary education and training in colombia
M. Chaparro, A. Guerrero, V. Arcila, V. Quintero

III-3-881
Three databases for alternatives in education and training
N. Jukes, V. Danko, D. Leporsky

Session III-5: Sharing best practices in LAS education and training

III-5-662
Students’ perception of e-learning in Laboratory Animal Science training
A. Costa, A. Costa, I. A. Olsson

 

Theme IV – Communication, Dissemination and Data Sharing

Session IV-2: Scientific reporting standards (in vivo and in vitro)

IV-2-111
Study on the scientific validity of animal experiments in Switzerland
T. S. Reichlin, L. Vogt, H. Würbel

Session IV-3: Retrospective analysis / non-technical summaries (2010/63)

IV-3-334
Public openness in laboratory research: a survey study
E. Kwok, E. H. Ormandy, D. M. Weary

Session IV-4: Information systems and databases

IV-4-035
The Status of a New Database Construction for the Safety Results of Korean Alternative Researches
K.-H. Park , B.-H. Kim

IV-4-459
Monitoring and evaluation of developments in animal use and 3R-alternatives
S. Deleu, M. van Zijverden

IV-4-476
Use of ASPCA Animal Poison Control Center’s Toxicology Database for Characterizing Toxicity of Human Medications in Pets
S. Khan, M. McLean

IV-4-607
3R Guide: a new database of 3R resources
A. Smith, T. Allen, Ø. Wærenskjold

IV-4-686
The EURL ECVAM Search Guide – promoting global standards for searching 3Rs information
A. J. Roi, B. Grune, Jon Richmond

IV-4-915
An optimized hypothermic storage medium capable to maintain histology and functions of skin tissue and allow epidermal stem cell isolation
C. Chesné, N. Rougier, M.Kermorvan

 

Theme V – Efficacy and Safety Testing of Drugs and Biologicals

Session V-1: Pathways based assays in drug development

V-1-011
Cardiotoxicity of captopril in chick embryos
Y. Yoshiyama, T. Tamaki, T. Kozuki, M. Okayasu, T. Miyazaki, M. Kawakami, H. Ariumi

V-1-018
A zebrafish bioassay to evaluate gastrointestinal function
T. B. Cole, S. C. Cassar, J. J. Lynch, S. L. Koeniger, K. Hempel, W. R. Buck, H. Yang, H. Lorenz, B. Tornesi

V-1-019
Inhibitory effects of ambroxol on type A seasonal influenza virus infection in vitro
T. Tamaki, H. Ariumi, Y. Yoshiyama

V-1-051
Electron Paramagnetic Resonance (EPR) Spin Labeling Study of HT-29 Colon Adenocarcinoma Cells after Hypericin-Mediated Photodynamic Therapy
A. Kılıç Süloğlu, D. Yonar, M. M. Sünnetçioğlu, G. Selmanoğlu

V-1-083
Nerve-muscle-cultures as an in vitro tool for pharmacologic testing
V. Eckle, C. Grasshoff, B. Antkowiak

V-1-161
Use of upcyte® human hepatocytes to CYP inhibition and induction screening
S. D. Ramachandran, N. J. Hewitt, R.Eudenbach, S. Heinz, B. Muenst, J. Braspenning

V-1-401
Trypanosoma cruzi: in silico and in vitro alternatives for identifying new antiparasites
S. C. Bourguignon , H. P. Araújo, G. C. Lechuga, S. B. Nascimento, A. L. Lourenço, V. F. Ferreira, H. C. Castro

V-1-506
Antithrombotic potential of synthetic 1,2,3-triazoles evaluated through in vitro and in silico approaches
L. Moura, A. de Almeida, A. da Silva, S. Ferreira, V. Ferreira, A. Fuly

Session V-2: Disease models in vivo

V-2-064
Comparative assessment of cytotoxic effects of garlic oil and 2,2'-dithio-bis(N,N-diethyl)ethanamine on human umbilical vein endothelial cells in culture
D. Prokofeva, N. Goncharov

V-2-386
Trends in the use of genetically modified mice and their efficacy as a model for human disease
K. Coll, A. Bennett

V-2-903
Diet-induced iron deficiency anemia in rats – in vivo model
J. Reguła, J. Suliburska, E. Król, Z. Krejpcio

V-2-931
Role of drug transporters in pancreatic adenocarcinoma therapy
M. Ehrlichova, M. Kocik, B. Mohelnikova-Duchonova, V. Brynychova, K. Elsnerova, V. Hlavac , M. Oliverius, E. Honsova, J. Mazanec, J. Hlavsa, Z. Kala, P. Soucek

Session V-3: Potency testing of human and veterinary vaccines

V-3-057
Thermal imaging - alternative concepts for refinement and reduction of animal use for testing of biologicals
A. Hoffmann, C. Dumke, F. Mohs, E. Balks, J. Hermans, M. Bernau, P. Kremer, M. Toda, U. Salge-Barthels, K. Cussler

V-3-170
An Animal-free Batch Testing Method for Alum-Adjuvanted Veterinary Rabies Vaccines
V. Jakel, K. Duchow, B. Kraemer, M. Bastian

V-3-201
Notes on the validation of Vero cell test for the absence of residual diphtheria toxin
F. A. Freitas, J. Kapronezai, W. Quintilio

V-3-203
A serological assay to determine the potency of inactivated rabies vaccines for human use
B. Kraemer, H. Schildger, H. Wegner, V. Euteneier, J. Klimek, K. Duchow

V-3-249
In vitro characterization of adjuvant biological activity and safety
S. Richard, M. J. Diana, P. Probeck, J. Haensler, A. Saulnier, N. Nougarede

V-3-321
Development of relevant serological methods for replacing in vivo seroneutralization tests used for determining Potency of Diphtheria, Tetanus and whole-cell Pertussis vaccines
M. L. Chovel, A. Mandiarote, N. Gutiérrez, L. Herrera, J. F. Núñez, O. Valle, I. Ontivero, T. Mahy

V-3-339
Study on the establishment of Standard material for pertussis toxin and Standard pertussis strain
J.-I. Ahn , H. Oh, K. Kim , H. Song , H. Kim, S. Lee, M.-Y. Bae, J. Park, S. Kim, J.-G. Kim

V-3-351
Determination of Effectiveness of Immunized Chickens’s Immuneglobuline Y against Salmonella Infection in Mice
H. Hadimli, Z. Sayin, A. Sakmanoglu, G. Sanioglu

V-3-384
Study of an Alternative pyrogen test for blood product
J.-H. Kim, J.-Y. Lee, D.-H. Ryu, Y.-S. Kang, W.-H. Lee, H.-O. Kim, H.-K. Oh, Y.-L. Kim, K.-T. Nam, C.-Y. Ahn

V-3-458
Potency evaluation of Bothrops snake venom: a cytotoxicity assay as an alternative to the murine model
H. Araujo, D. F. B. Cavalcanti, A. L. Fuly , S. C. Bourguignon

V-3-480
Evaluation of serological test for whole cell pertussis DTP vaccine
J. Kapronezai, F.A. Freitas, W. Quintilio

V-3-512
Optimisation of an in vitro assay system as an alternative to current murine histamine sensitization test for acellular pertussis vaccines
K. Markey, C.T. Yuen, C. Asokanathan, A. Douglas-Bardsley , D. Xing

V-3-596
Development of a common immunogenicity assay on guinea pigs for the potency testing of multicomponent vaccines
M. Chabaud-Riou, F. Guinchard, C. Lyonnais, A. Lefebvre, S. Guichard, S. Perrin, S. Imbert, S. Uhlrich, D. Gaillac, D. Petre

V-3-773
Avian encephalomyelitis live vaccines - alternative methods for batch testing
L. Rimpel, S. Haege, D. Loos, C. Jungbaeck, A. Motitschke

V-3-917
Refinement and reduction of 3R; in vivo imaging method can refine experimental procedures with less number of animals
K.-J. Hong, P.-G. Park, Y.-H. Kim, Y.-W. Shin, G.-E. Rhie, H. Youn, S. Y. Han

V-3-949
The BINACLE (binding and cleavage) assay allows in vitro detection of active tetanus neurotoxin in vaccines
H. A. Behrensdorf-Nicol, U. Bonifas, K. Weißer, B. Krämer

Session V-4: Medical devices and Biologicals

V-4-070
Magnetic resonance imaging – a way to reduce animal numbers for safety testing of veterinary medicines
M. Bernau, P.V. Kremer, L.S. Kreuzer, E. Pappenberger , K. Cussler, A. Hoffmann, D. Emrich, M. Leipig, W. Hermanns, A.M. Scholz

V-4-135
Pulmonary artery hemostasis: a model for surgical stapling and sealing
C. Henderson

V-4-196
In-vitro potency determination of botulinum neurotoxins A and B
E. Wild, H. A. Behrendsorf-Nicol, U. Bonifas, B. Kegel, B. Kraemer

V-4-256
Generation of neurons derived from stem cells and cell lines to develop cell based replacement assays for botulinum toxins and antitoxins
N. Bak, B. Englich, C. Rasetti-Escargueil, D. Sesardic

V-4-267
Pred-Immune; A novel integrative statistical approach for the prediction of the risk of immunogenicity of biologics
G. J. D. van Mierlo, R. H. Klein Entink, M.-L. H. M. H. de Zeeuw-Brouwer, F. J. Tielen, C. A. M. Krul, B. O. Fabriek

V-4-365
Photographic evaluation of skin lesions in batch potency testing of tuberculins – a reduction approach
E. Balks, C. Dumke, F. Mohs, K. Cussler, E. Werner, A. Hoffmann

V-4-461
Local lymph node assay on five medical devices including dental materials for alternative safety evaluation
I. L. Ahn, S. Y. Park, J. Y. Yang, S. Y. Kim, J. S. Lee, J. H. Lee, T. S. Kim, K. H. Choi

V-4-593
Towards a full-function molecular-based assay for Botulinum Neurotoxin
G. B. Stevens, T. Binz, W. Römer, T. van Oordt, G. A. Urban, R. Zengerle, F. von Stetten

V-4-599
An alternative micromethod to assess the procoagulant activity of Bothrops jararaca venom and the efficacy of antivenom
N. Oguiura, J. Kapronezai, T. Ribeiro, M.M.T.Rocha, C.R.Medeiros, J.R.Marcelino, B.C.Prezoto

V-4-717
Development of tridimensional murine and primary human osteoblastic cells models for biocompatibility studies
L. Restle, D. Costa, E, Lourenço, R. Bachinski, A. Linhares, G. Alves

V-4-724
The application of rat hepatocyte aggregate for cytotoxity assay
M. Shinohara, K. Komori, T. Fujii, Y. Sakai

V-4-727
Development of a Mock Circulatory System for Evaluation of Mechanical Heart Valves
M. Ross, S. Gregory, G. Tansley, M. Pearcy

V-4-871
Applicability of Monocyte Activation Test (MAT) in the routine of the quality control laboratory
C. Caldeira, O. Presgrave, A. Moraes, I. Delgado

V-4-872
Monocyte Activation Test (MAT): identification of monographs that recommend Rabbit Pyrogen Test (RPT) and Bacterial Endotoxin Test (BET) as a kick-off for showing applicability of MAT
C. Caldeira, M. Cruz, J Freitas, O. Presgrave, A. Moraes, I. Delgado

V-4-873
Assessment of pyrogenic contamination with Lipoteichoic Acid (LTA) in the Monocyte Activation Test (MAT) and Rabbit Pyrogen Test (RPT)
I. Gimenes, C. Caldeira, O. Presgrave, M. Villas-Boas

V-4-946
Isolation of Shiga Toxin-Producing Escherichia coli (STEC) Using Magnetic Beads
J. H. Kim, S. J. Lee, K. W. Seo, S. Y. Han, Y. H. Kang, G. T. Chung

 

Theme VI – Human Relevance

Session VI-1: In vitro disease models

VI-1-009
Evaluation of in vitro inhibitory effect of Enoxacin on Babesia and Theileria parasites
M. A. Omar, M. A. Rizk, S. M. Elsayeda, A. ElSify, A. A. Salama, S. S. AbdElgayed, N. Yokoyama, I. Igarashi

VI-1-025
Inter-laboratory validation of an innovative huFcERIa-RBL-2H3 degranulation assay for in vitro allergenicity assessment of whey hydrolysates
K. Knipping, M. van Roest, L. Kruijssen, M. Smits, L. Cox, N. de Jong, P. Simons, R. Teshima, L. Knippels, R. Pieters

VI-1-192
An assessment of the cell stress response of lung epithelial cells exposed to cigarette smoke aqueous extracts
M. Taylor, G. Moore, T. Carr, N. Cockcroft, F. Lowe, G. Phillips

VI-1-434
In vitro models for neuroimmunological diseases
S. M. Burm, E. A. Zuiderwijk-Sick, J. Veth, C. van der Putten, A. E. 't Jong, P. M. Weert, J. J. Bajramovic

VI-1-472
Simulating the first phase of bone fracture healing in vitro – Possible or not?
A. Lang, P. Hoff, J. Neuhaus, I. Ponomarev, D. Barnewitz, F. Buttgereit, T. Gaber

VI-1-568
A model of neuronal hyperreactivity in passive sensitized human organotypic tissue
S. Schindler, S. M. Jimenez-Delgado , A. Braun, K. Sewald

VI-1-571
Human organotypic cancer model
S. Konzok, S. Schindler, A. Braun, K. Sewald

VI-1-578
Nucleus pulpous and annulus fibrosus cell isolation from human intervertebral disc
L. Gradisnik, T. Velnar

VI-1-723
Validation of a mock circulation loop for the development of ventricular assist devices with physiological data
J. Fröhlich, J. P. Pauls, S. D. Gregory

VI-1-730
Low concentrations of cigarette smoke extract act cytotoxic on human alveolar epithelial cells type II
S. Seehase, B. Baron-Luehr, C. Kugler, E. Vollmer, T. Goldmann

VI-1-788
Chorioallantoic membranes as a living support for skin and human tumor cells xenografts
H. Dabboue, G. Marti-Mestres , J-P. Molès, L. Meunier, X. Rebillard, P. Nirdé

VI-1-840
Application of in vitro skin models for cosmetic product efficacy: UV protection, skin lightening, skin hydration and anti-aging
M. Bachelor, A. Armento, B. Breyfogle, G. Stolper, J. Oldach, M. Klausner, P. J. Hayden

Session VI-2: Use of stem cells in screening

VI-2-040
Genome-wide gene expression analysis by RNA-seq in murine embryonic stem cells
H. Tani, J. Takeshita, H. Aoki, M. Gamo, M. Torimura

VI-2-330
Establishing an in vitro screening test for developmental neurotoxicity
J. Huang, S. Cheng

VI-2-445
Human in vitro adipogenesis assay for testing modulators of adipogenesis
O. Huttala, JR. Sarkanen, T. Ylikomi, T. Heinonen

VI-2-664
Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell‑based test battery
G. Pallocca, B. Zimmer, N. Dreser, T. Waldmann, K.H. Krause, C. van Thriel , J. Hengstler, A.Sachinidis, S. Bosgra, M. Leist

Session VI-3: Human biomarkers

VI-3-005
Funding innovation to foster decreases in compound attrition and the 3Rs: a new process
G. Dal Negro

VI-3-411
Proton magnetic resonance spectroscopy and recursive partitioning analysis of brain metabolism data from an Alzheimer’s disease cohort offers a replacement alternative for animal studies on disease prediction
A. C. Londono, F. X. Castellanos, A. Arbelaez, A. Ruiz, D. C. Aguirre-Acevedo, A. M. Richardson, S. Easteal, B. A. Lidbury, M. Arcos-Burgos, F. Lopera

VI-3-823
From transient transcriptome responses to disturbed neurodevelopment: divergent response patterns and epigenetic modifications triggered by the same drug
S. Klima, N. V. Balmer, E. Rempel, A. Sachinidis, J. G. Hengstler, J. Rahnenführer, T. Waldmann, M. Leist

VI-3-825
Waves of gene expression as basis to define windows of sensitivity for developmental neurotoxicity
N. Dreser, N. Balmer, S. Klima, T. Waldmann, M. Leist

Session VI-4: Absorption, distribution, methabolism and excretion (ADME)

VI-4-213
Porcine buccal mucosa as an in vitro route model for systemic drug delivery evaluation
M. Sacha, H. Haltner

VI-4-276
Biotransformation of testosterone and 2,4-toluenediamine by human skin and reconstructed tissues
L. Grohmann, W. Klipper, M. Schäfer-Korting, G. Weindl

VI-4-277
Characterization of monoamine oxidases, steroid-5α-reductases, sulfotransferases and glutathione S-transferases in reconstructed skin tissues and human skin ex vivo
L. Grohmann, M. Schäfer-Korting, G. Weindl

VI-4-390
Influence of receptor fluid on dermal absorption of caffeine
K. Trenz, S. Bruszies, H. Hofman-Huether

VI-4-479
Microdosing of New Biological Entities (NBEs) in healthy volunteers: a safe and fast tool to predict clinical pharmacokinetics
M. L. H. Vlaming, E. van Duijn, R. Brands, A. D. Windhorst, N.H. Hendrikse, S. Bosgra, M. C. de Koning, W. Seinen, P. A. M. Peeters, W. H. J. Vaes

VI-4-528
A comparison of xenobiotic metabolism enzyme profiles in human skin and in vitro skin models
N. J. Hewitt, F. Fautz, P. Fowler, J. Kenny, A. Latil, G. Quedraogo, K. Reisinger, M. Klaric, P. Pfuhler

VI-4-836
Prediction of the brain distribution of drugs in human using in vitro human blood-brain barrier model derived from stem cells
R. Cecchelli, D. Hallier-Vanuxeem, S. Aday, M. Culot, E. Sevin, C. Almeida, M.-P. Dehouck, L. Ferreira

Session VI-5: Epithelial biobarriers

VI-5-281
Establishment of an intestinal model for oral vaccination testing
C. Lotz, M. Schweinlin, H. Walles, M. Metzger

VI-5-299
Full-thickness tissue engineered development using human keratinocyte and adipose tissue derived mesenchymal stem cells
R. C. Mosca, D. Steffens, C. Pelissari, A. Mantesso, M. B. Mathor

VI-5-354
HuIFN-αN3 and 10% PBS Holocene grain wash-out affect the Glutathione and lipid peroxidation in CaCo-2 cells
B. Filipic, L. Gradišnik, S. Koren, E. Šooš, H. Mazija

VI-5-569
Evaluating reconstructed cutaneous squamous cell carcinoma
C. Zoschke, H. F. Merk, S. Küchler, G. Weindl, M. Schäfer-Korting

VI-5-822
Evaluation of serum growth factors in wound healing using a full-thickness in vitro human skin model
M. Bachelor, A. Armento, G. Stolper, J. Oldach, M. Li, M. Klausner, P.J. Hayden

VI-5-926
Use of reconstructed human epidermis as alternative models for efficiency studies against the penetration of organophosphates
C. Bignon, D. Josse, S. Amigoni, E. Taffin de Givenchy, J. Pelletier, S. Briançon, F. Guittard

 

Theme VII – Ethics

Session VII-2: Ethics of using animals

VII-2-076
Virtue ethics: an ethical approach for non-clinical drug development?
M. Spatzenegger

VII-2-090
A patient tail
J. Johnson, C. McLeod

VII-2-149
Animal rights and ethics in research: Is it possible a non-speciest approach?
J. J. Rocha

VII-2-151
A system for retrospective assessment of cumulative severity to identify targeted refinements
S. Wolfensohn, M. Dennis, S. Sharpe

VII-2-184
Openness and accountability of animal research: a focus group study with local stakeholders at a Canadian university
E. Ormandy

VII-2-230
Trends in animal use at US research facilities
J. R. Goodman, A. Chandna, K. V. Roe, S. H. Suiter

VII-2-402
1R is the new 3Rs
C. Redmond

VII-2-413
The curious language of animal research and how it jeopardizes the public trust
F. McMillan

VII-2-414
Life after research: the psychological well-being of animals following release from the laboratory
F. McMillan

VII-2-616
Animal experimentation: transparency and public concerns
K. Herrmann

VII-2-628
Emerging Trends in Alternative to Animal Experimentations
N. Verma

VII-2-794
Attitudes on animal use shown by scientists at workshops in Taiwan
D. Fry, M. Jennings, P. Littlefair

VII-2-911
The harm-benefit analysis within the evaluation of animal experimentation projects. How to assess criteria like species, number of animals or death of animals?
V. Marashi, N. Alzmann, H. Grimm

VII-2-948
Using minipigs in pre-clinical studies in Russia
A. Rybakova, A. Selezneva

Session VII-3: Ethical evaluation

VII-3-055
Environmental Impacts of Animal Research and Testing
K. Groff, T. Capaldo

VII-3-138
Analysis of animal experimentation oversight committee membership at US institutions
A. Chandna, L. A. Hansen, J. R. Goodman

VII-3-139
Great ape disgrace: how the US laboratory oversight system failed chimpanzees
J. R. Goodman, A. Chandna

VII-3-403
Germany: Animal welfare representative legal action and its effects on animal experimenting
C. Baumgartl-Simons, C. Hohensee, C. Ledermann

VII-3-726
German animal welfare act in breach with Directive 2010/63/EU
I. Ruhdel, K. Wagner, R. Kolar

VII-3-844
The “benefits” standard: how can it better protect animals?
M. Matevia, A. Rowan

Session VII-4: Distress evaluation

VII-4-059
Norecopa: using a national consensus-platform to promote the 3Rs
A. Smith

VII-4-410
Emotional pain: why it can matter more to animals than physical pain
F. McMillan

VII-4-412
The complexity of animal well-being: advances in our understanding of quality of life, welfare, and happiness – and why it matters in animal research
F. McMillan

Session VII-5: Benefit evaluation

VII-5-307
Benefit evaluation within project evaluation under directive 2010/63/EU
D. Anderson, S. Louhimies

 

Theme VIII – Refinement and Welfare

Session VIII-1: Non-human primate use and welfare

VIII-1-359
European Primate Network EUPRIM-Net II: Advancing 3Rs and international standards in biological and biomedical research
V. Stephan, B. Pauling, R. Teepe, S. Treue

VIII-1-360
A cage-based behavioural testing system for NHP – Towards a cognitive neuroscience without restrained animals
M. Niessing, M. Berger, L. Burchard, A. Calapai, K. Heisig, V. Stephan, S. Treue, A. Gail

VIII-1-408
Using an automated system of positive reinforcement training to refine the process of behavioural training and reduce the need for food control in rhesus macaques
J. Tulip, J. B. Zimmermann, F. de Carvalho, D. Farningham, A. Jackson

VIII-1-681
Optimisation of preclinical use of Non-human primates (NHP) by species-specific Monocyte activation test (MAT)
J. Hermanns, C. Bache, E. Holznagel, B. Becker, J. Kaiser, I. Spreitzer

Session VIII-2: Best practice welfare approaches – Mouse

VIII-2-012
Microenvironment in reusable and disposable individually ventilated cages: a comparative study
L. Contalbrigo, G. Milite

VIII-2-034
Husbandry and enrichment for the recently protected common European cuttlefish (Sepia officinalis)
G. M Cooke, B. M. Tonkins

VIII-2-045
Refinement and efficiency through serial microsampling – cost/benefit analysis
N. Bratcher, P. Ebert, W. Buck, L. Medina

VIII-2-071
Vaccination in lambs – An animal welfare issue?
M. Bernau, P. V. Kremer, L. S. Kreuzer, S. Schwanitz, K. Cussler, A. Hoffmann, M. Leipig, W. Hermanny, A. M. Scholz

VIII-2-105
Refining oral gavage: assessing and improving welfare in the laboratory-housed dog using a Welfare Assessment Framework
L. Hall, S. Robinson, H.M. Buchanan-Smith

VIII-2-179
Refinement in pain relief in sheep fetal surgery
H.-M. Voipio, E. Heikkinen, S. Laaksonen, L. Haapala, A. T. Heikkinen, J. Räsänen, T. Erkinaro, G. Acharya, M. Kokki, H. Kokki

VIII-2-202
Putting animal welfare principles and 3Rs into action
K. Blumer

VIII-2-304
Severity classification in German animal research applications
K. Herrmann, P. A. Flecknell

VIII-2-305
Refinement in German animal research applications
K. Herrmann, P. A. Flecknell

VIII-2-327
Determination of the optimal dose of benzocaine hydrochloride in euthanasia of frogs (Rana catesbeiana)
A. Pereira, M. A. Lallo

VIII-2-372
Cognition studies refined with pet animals
M. Norring, S. Somppi, H. Törnqvist, L. Hänninen, O. Vainio

VIII-2-379
Assessing physiological and behavioral responses over time in laboratory beagles
L. Dietz, C. Bol, F. Ohl, A. Ortolani

VIII-2-460
Refinement strategies to improve the survival rate in mouse models for influenza A virus infections
M. Boldrin, A. Romero Tejeda, G. Beffagna, R. Aiello, I. Capua, C. Terregino, G. Cattoli, F. Mutinelli

VIII-2-553
Update on best practice approaches to the welfare and husbandry of fish, cephalopods and decapods
A. Smith, P. Hawkins, T. Kristiansen, C. Mejdell

VIII-2-562
Use of Eclipta prostrata extract prevents tissue damage induced by snake venoms immunization in horses during antiofidic serum production
M. A. Strauch, L. E. R. Cunha, P. N. C. Souza, L. R. Meirelles, P. A. Melo

VIII-2-579
Decreased use of experimental animals through optimization of experimental design for efficacy studies
R. Stoop, A. M. Zuurmond, J. R. O. Hanemaaijer, S. van Buuren, P. L. P. Van Loo

VIII-2-739
Stress response to blood sampling from dorsal pedal vein compared to saphenous vein in mice
S. Ledahl, N. Delaleu, P.Vogelsang

VIII-2-812
Health Monitoring of rodents in microisolation cages – A rationale approach (with an eye to the 3Rs)
M. Skowron

VIII-2-851
Laboratory mouse euthanasia: aversion and refinement
C. Moody, I. J. Makowska, D. M. Weary

Session VIII-3: Humane principles in experimental techniques and benefits of 3Rs

VIII-3-106
Principles of animal modelling in psychiatric research with respect to 3R rules
H. Tejkalová

VIII-3-736
Gavage incidents- a urgent need for action
K. Taylor, L. Rego

VIII-3-923
The development of hormone loaded diets to promote xenograft growth
A. Ritchie, P. Collier, N. Nicolaou, A. Grabowska

VIII-3-938
Humane principles of using animals in Russia
V. Makarov, M. Makarova, A. Selezneva, A. Rybakova

Session VIII-4: Avoidance of severe suffering

VIII-4-234
Promising in vitro alternatives for nutrition studies in cattle
A. B. Jacob, V. Balakrishnan

VIII-4-555
A road map towards ending severe suffering
E. Lilley, P. Hawkins, M. Jennings

Session VIII-5: Culture of care

VIII-5-400
Changing the culture of laboratory rat care
I. J. Makowska, J. Sato-Reinhold, D. M. Weary

 

Theme IX – Global Cooperation, Regulatory Acceptance and Standardization

Session IX-1: Activity updates from international scientific societies

IX-1-159
The International Society for In Vitro Methods (INVITROM)
J. van der Valk, R. Cortvrindt, S. Horbach, T. Vanhaecke, H. Witters

IX-1-198
'GUTS in the LAB’ – Award for courageous scientists doing excellent 3R research
M. Kuil, M. F. Schilders-van Boxel

IX-1-514
Science and awareness: a journey inside the 3Rs – Didactic exhibition project
V. Romanelli, P. Costa, P. Granata, A. Stammati, F.Zucco, F. Caloni, F. Fassio, I. Ferri, M. Kuan, M. T. Iela, A. Vitale, I. De Angelis

IX-1-718
COLAMA2012 – the first Latin American congress on alternatives
G. Alves, R. Bachinski, C, Caldeira, L.B. Ballotin, O. Presgrave, J.M. Granjeiro

Session IX-2: Animal welfare implementation across the world

IX-2-056
3Rs Dissemination in Asia: Zebrafish embryo toxicity test transferred in Sri Lanka’s universities
F. Busquet

IX-2-088
Animal welfare implementation in Switzerland: A successful stakeholder approach based on a joint Animal Welfare Charter
C. Lorber, T. Schnitzer, K. Blumer, J. Coenen

IX-2-091
5 Years InVitroJobs – Internet Platform, Job Board and Working Group Network for animal-free research
C. Hohensee, C. Ledermann, C. Baumgartl-Simons, S. Elsner

IX-2-145
Use of Animals in Military Medical Training by NATO Nations
J. R. Goodman, S. G. Gala, M. J. Balsam, M. P. Murphy

IX-2-328
A new guideline about euthanasia to laboratory animals in Brazil
A. Pereira, M. A. Lallo

IX-2-500
Legislation and implementation of alternative methods and outcomes
T. Titma

IX-2-604
The transposition of directive 2010/63/EU on the protection of animals used for scientific purposes – a comparison between France, Germany, the United Kingdom and Austria
J. Ricken

IX-2-790
3R work structured according to Lean Sigma results in increased refinement and reduction in toxicity testing in the pharmaceutical industry
C. Vult von Steyern, H. Hellmold, I. Cotgreave, B. Platzack, M. Öberg, E. Törnqvist

IX-2-806
Alternatives in South Africa: Initiatives in education, research and testing
E. Vercuiel, N. Jukes, L. Sentle, T. Lotter

IX-2-821
India takes a giant step forward to protect dogs from testing, with more emerging evidence that dogs add no additional value in toxicity testing
S. Tettamanti Pereira, M. Thew, J. Bailey

Session IX-3: Activity updates from international validation centres

IX-3-870
The Brazilian Center for Validation of Alternative Methods (BraCVAM) and the National Network on Alternative Methods (RENAMA): the first years of activities
O. Presgrave, W. Moura, C. Caldeira, L. Balottin, I. Delgado, J. Granjeiro, E. Santos, M. Villas-Boas

IX-3-895
In Vitro Laboratory GLP-Certified in Brazil: a successful public-private partnership to achieve international harmonization
F. Medeiros, T. Franco da Cunha, O. Zazuco Higa

Session IX-5: Regulatory acceptance of alternatives

IX-5-478
Read across strategy for the assessment of dyes with the aid of a new QSAR system
V. Alberti, C. Rovida, V. Consonni, M. Locatelli, R. Todeschini, M. Kahlberg

IX-5-530
SLiM: a smart way from innovations to humans
C. Krul, D.Kegler, L.M'Rabat, R. Pieters, J. Raaijmakers, M-J Schiffelers, M.Teunis, J. van der Valk, R. Vandebriel, R. Woutersen

IX-5-691
Developing Regulatory Acceptable In Vitro Methods
C. S. Roper, D. A. Murray, J. Welch, S. Madden

IX-5-770
On cosmetics animal testing and be Cruelty free campaign in China
Y. Zhang

IX-5-800
Good In Vitro Method Practice (GIVIMP): Guidance on the implementation of in vitro methods within a GLP environment to support regulatory human safety assessment of chemicals
S. Coecke

IX-5-880
Considerations for Alternatives to Non-human Primates in Preclinical Safety Assessments
B. Li, X. Geng

Session IX-6: Breaking down barriers and promoting international cooperation on 3Rs

IX-6-075
Science Communication in Alternatives to Animal testing: Raising awareness beyond the community
F. Busquet

IX-6-109
Regulatory acceptance and use of 3R models for pharmaceuticals and chemicals: Expert opinions on the state of affairs and the way forward
M.-J. Schiffelers

IX-6-195
A decision tree to facilitate the replacement of laboratory animals in Brazil
V. C. Bones, C. F. M. Molento

IX-6-199
Ban safety tests on animals
M. Kuil

IX-6-214
Animal use and cost estimates for the proposed US policy on cosmetics – Comparison with EU and other World States
J. Knight, C. Rovida

IX-6-255
Cost Comparison between the Mouse Inoculation Test (MIT) and the Virus Isolation in Cell Culture (VICC) for rabies diagnosis
V. C. Bones, A. H. Gameiro, J. G. Castilho, C. F. M. Molento

IX-6-444
Combining 3R strengths in the international arena: together we are strong!
S. Deleu

IX-6-697
Working to reduce the use of animals in scientific research – a national approach
W. Reynolds, H. Bodmer, J. MacArthur Clark, K. Dunsford, P. Earl, D. Jones, R. Mueller, V. Robinson, L. Godden

IX-6-795
Cooperative industry activities to support international advancement of non-animal testing methods
E. Hill, Q. Zhang, R. Curren

Session IX-7: Harmonising ways to capture pathway-knowledge in toxicology

IX-7-860
Quality assurance of emerging technologies in toxicology
M. Bouhifd, T. Hartung

 

Theme X – Additional sessions

Session X-2: Cosmetics around the world

X-2-758
The LUSH non-animal testing policy
H. Jones

Session X-3: Special lectures

X-3-175
Björn Ekwall memorial foundation
A. Kolman, H. Tähti

 

Last update: 22 August 2014